La maladie de Parkinson au Canada (serveur d'exploration)

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Dementia, parkinsonism, and motor neuron disease: Neurochemical and neuropathological correlates

Identifieur interne : 004C30 ( Main/Exploration ); précédent : 004C29; suivant : 004C31

Dementia, parkinsonism, and motor neuron disease: Neurochemical and neuropathological correlates

Auteurs : Douglas S. Gilbert [Canada] ; Stephen J. Kish [Canada] ; Li-Jan Chang [Canada] ; Caryl Morito [Canada] ; Kathleen Shannak [Canada] ; Oleh Hornykiewicz [Canada, Autriche]

Source :

RBID : ISTEX:46BD57A6A357E678D7B4259681DF0F2AE00797F3

English descriptors

Abstract

The neurochemical Marchkers for the major neurotransmitter systems were measured in the brain of a patient who died with a dementia‐parkinsonism‐motor neuron disease (DPMN) syndrome complex. Moderate neuronal loss in the substantia nigra, spongiform changes in the frontal cortex, and moderate anterior horn cell loss throughout the spinal cord were observed. A severe nigrostriatal dopamine deficiency provides the basis for the observed parkinsonian features. The dementia is unexplained.

Url:
DOI: 10.1002/ana.410240518


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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